'It's a once in a career
feeling'
Study
with ‘powerful results’ finds that combining two existing therapies could
extend the life of men with advanced, high-risk prostate cancer by 37%
Combining two existing
prostate cancer therapies could extend the life of men with advanced, high-risk
prostate cancer by 37%, according to a study presented at the world’s largest
cancer conference. The new findings could change how doctors first approach
treatment of prostate cancer.
“These are the most
powerful results I’ve seen from a prostate cancer trial,” said Nicholas James,
the lead author of the abstract presented as the American Society of Clinical
Oncology. “It’s a once in a career feeling. This is one of the biggest
reductions in death I’ve seen in any clinical trial for adult cancers.”
Researchers combined
standard hormone therapy with a drug called abiraterone , which is typically
used only for cancer patients whose disease has stopped responding to standard
hormone therapy. The research was conducted as part of the Stampede trial, an
ongoing randomized trial conducted in the UK and Switzerland.
“Abiraterone not only
prolonged life, but also lowered the chance of relapse by 70% and reduced the chance
of serious bone complications by 50%,” James said. “Based on the magnitude of
clinical benefit, we believe the upfront care for patients newly diagnosed with
advanced prostate cancer should change.”
The study looked at a
group of 2,000 men. Patients who received both abiraterone and normal hormone
therapy were significantly less likely to die, compared to patients who
received only hormone therapy.
Comparatively, 83% of men
assigned abiraterone therapy survived versus 76% of men on standard hormone therapy.
Researchers also found that patients who received both medications had slightly
stronger side effects, especially cardiovascular and liver problems.
One patient who
participated in the trial, Alfred Samuels, 59, was diagnosed with advanced
prostate cancer in January 2012. “It felt like my world fell apart overnight,”
Samuels said. “The doctors explained that surgery wasn’t an option for me
because the cancer had spread beyond my prostate.”
“As part of the trial, I
started taking abiraterone four times a day and had a hormone injection every
eight weeks,” he said. “During the first six months, tests showed that the
treatment was working. I’m still on the trial, which I find reassuring and,
fortunately, my cancer is being managed well.”
More than 27,000 men in
the US and 11,000 men in the UK die of prostate cancer each year, according to
the US Centers for Disease Control and Prostate Cancer UK. In the US, aside
from skin cancer, it is the most common cancer in men.
“The potential benefits of
giving some men abiraterone alongside hormone therapy are clearly impressive
and we will be working with all relevant bodies to make sure this treatment
becomes an option available for these men via the
NHS,” said Dr Iain Frame, director of research at Prostate Cancer UK.
Source: The Guardian
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